Primitive Neuroectodermal Tumor of the Kidney

Authors

  • Abbas Ali Omidi Dept of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
  • Ali Shamsa Dept. of Urology, Mashhad University of Medical Sciences, Mashhad, Iran
  • Amir Hossein Jafarian Dept of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
  • Saeedeh Khajeh Ahmadi Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The cells of tumor express CD99, vimentin, NSE, FL1 but do not express Ck, LCA, myogenin, and WT1. We present a 36-year –old female with left –side tender abdominal swelling, and history of trauma to abdominal. CT imaging confirmed a huge solid mass of kidney, also extending into renal pelvis. Histological section of the lesion showed a malignant proliferation of small round cells in rosette-like pattern with foci of necrosis area. Tumor cells expressed high level of CD 99 antigen. The diagnosis of the lesion was primitive neuroectodermal tumors (PNET). Following-up after 6 months showed no recurrence.  

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Journal title

volume 8  issue 2

pages  123- 126

publication date 2013-04-01

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